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1111 Gene ResultCHEK1 checkpoint kinase 1 human ~ The protein encoded by this gene belongs to the SerThr protein kinase family It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA This protein acts to integrate signals from ATM and ATR two cell cycle proteins involved in DNA damage responses that also associate with chromatin in meiotic prophase I Phosphorylation of
3845 Gene ResultKRAS KRAS protooncogene GTPase human ~ The HSF1BAG3Mcl1 signal axis is critical for protection of mutant KRAS colon cancer cells from AUY922induced apoptosis Study results indicate that pleural homed cancer cells harboring activating KRAS mutations are competent of malignant pleural effusion induction This genotypephenotype link is primarily mediated via mutant KRASdependent CCL2 signaling that results in the recruitment of
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